Retinol Rejuvenation Serum delivers the maximum concentration of 5% retinol in a serum to influence collagen and speed skin renewal to diminish the appearance of fine lines, acne, wrinkles, and hyperpigmentation. Directions: Main Category Type: Serum Skin Type: Combination, Oily Four Step: Treat Directions Use after cleansing. Apply serum to the face, neck and décolleté. Finish with your GlyMed Plus Moisturizer of choice. Can be used once a day, preferably at night. Benefits: Reduce Dull & Uneven Texture Brightens Reduce Fine Lines & Wrinkles Reduce Pigmentation. Dark Spots Concerns: Acne Dark Spots Pores & Texture Pre-Treatment Preventative Wrinkles & Fine Lines