What it is: A skincare must-have and our #1 best seller, Dermaquest Essential B5 Hydrating Serum is a silky, weightless serum that provides an essential first step to any routine, delivering extraordinary, multi-tiered hydration to each and every cell and making smooth, supple, restored skin your new normal. ideal as a standalone serum or to prime the skin for layering additional serums. What it does: With daily use, Dermaquest Essential B5 Hydrating Serum fortifies the skin’s moisture barrier, making it stronger than ever and helping to reduce inflammation and redness, leading to optimal moisture retention, radiance, and skin density.