Crème PIGM 400 is a concentrate of active ingredients that brightens and protects skin, while reducing the appearance of dark spots. It is specially formulated as both a preventive and corrective treatment, helping reduce the intensity of existing pigment spots and prevent the appearance of new blemishes. The complexion becomes more radiant, and skin is more uniform. The main pigment of the marks is melanin. It is synthesized in the epidermis by cells known as melanocytes. Excessive melanocyte stimulation leads to the excess production of melanin and, consequently, skin hyperpigmentation. The main factor is the sun which, by stimulating a number of mediators (?-MSH or endothelin), forms brown marks on the skin’s surface.