Zx10 application. Very very important...says this on the bottle, its a very very strong formula , all 5 ingredients when layered onto to skin travel together to reach the point of pain and inflammation. It's an Amazing product but if used incorrectly is too hot , it had to be this strength to reduce inflammation and start to address the route course not just MASK the pain. This has been approved by Oxford sciences/ ISO which is hard to get as its higher than just a CSDR You literally spread on...DO NOT RUB it will activate in the epidermis too fast and it will feel like boiling water. Hence do not shower BEFORE or AFTER The amount in my hand is enough for a whole hip and back of the hip. If you have cysts under the skin apply above and below...DO NOT apply to cysts as they are fluid based. When treating Lymphodema as that also is lymph/ based please only apply to Lymphatic exits. Lipedema however those that have tried it found it helped their limbs move when applied directly