Active Ingredients Mandelic Acid · Ascorbic Acid · Arbutin · Melanostatine · Niacinamide · Magnesium Sulphate · Retinal Mode of Action Its ingredients effectively reduce the mRNA synthesis required for tyrosinase production, which when stopped, reduces melanin synthesis too. They also block melanosome release, along with clearing and homogenising the pigment. Treatment Protocol Use for product for at least 90 days, although the doctor will decide the total treatment duration. Application Protocol After cleansing the facial skin, apply a thin layer over the entire skin, massaging it in until fully absorbed. In case of irritation, use every other day for two or three weeks, before continuing to apply it daily.