Skin Medication No. 5 is one of the most effective topical treatments for inflamed and non inflamed acne. Once on the skin, benzoyl peroxide reduces bacteria by oxygenating pores, causing peeling and loosening of impactions to clear and prevent acne breakouts. After Cleansing and Serums. Apply a small amount to the affected areas. Use nightly or as directed. *Sleep on a white pillow case or towel as Benzoyl Peroxide causes lifting of color in towels and sheets.